Description
Achievements:
In vivo PK results for IV and IN administration:
•t1/2 plasma: 19 min
•t1/2 intranasal: 142 min
•DMTIN: 5 mg/kg (200x MIC)
•DMTIV: 40 mg/kg
No cytotoxic on HUVEC cells and keratinocytes / Absence of hemolysis on red blood cells /
Good lung exposure
Minimum Inhibitory Concentration: WT strains and clinical strains of A. baumannii : 3.25
μg/ml, 1.25 μM
MucilAir model of two resistant strains A. baumannii : efficacy at 50-100μM