New CB2 agonists for the Inflammatory Bowel Diseases treatment—Development of an active drug-candidate per os
Description
CB2 receptor is highly expressed in immune system and intestinal epithelium cells.
This receptor plays an important role in inflammation.
Studies have shown that a particular selective CB2 receptor agonist reduces colon inflammation in models of colitis induced by mustard oil or by dextran sulfate sodium (DSS).
Many pharmaceutical companies consider the CB2 receptor as a therapeutic target of interest for the treatment of chronic inflammatory diseases or neurodegenerative diseases.
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