ANTI AGE/ALE: Diamines anti AGE and ALE, chelators of metals and/or free radicals, active against skin aging
Description
AGEs (Advanced Glycation End products) are end-products resulting from the oxidative metabolism of carbohydrates.
These compounds are particularly involved in skin aging:
- Loss of skin tissue elasticity
- Skin pigmentation
ALEs (Advanced Lipid peroxidation End products) are end-products resulting from the degradation of polyunsaturated fatty acids under the effect of oxidative stress induced by transition metals.
These compounds are also involved in skin aging:
- Decreased skin resistance to UV.
To date, no existing compound makes it possible to inhibit the formation of AGEs and ALEs and to trap the transition metals.
Benefits:
- These new compounds are able to trap both the precursors of AGEs, those of ALEs but also to trap transition metals.
- Anti-radical and anti-apoptotic biological effects have been confirmed in vitro.
- Simple synthesis (5/6 steps), correct yield, low production cost, industrially transposable.
- Basic compounds which can be prepared in the form of salts.
- HET-CAM and skin irritation (Episkin) test successfully passed
- AMES test successfully passed
Sheet
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