Description
This technology is an alternative to techniques currently used to enhance transdermal drug delivery, such as iontophoresis, electroporation, and microporation.
• This technology is a new way to cross the stratum corneum using heat
. • The heat will destabilize the stratum corneum allowing the medication to pass through
• This technology is expected to expand the spectrum of drugs to be administered transdermally
• The patch is composed of 3 parts:
• a thin, flexible polymer support with high chemical and thermal resistance
• a thin nano-perforated metallic film transforming by Joule effect an electric current into heat
• a thin solid matrix containing a drug solution or suspension to be administered
Benefits:
- Non-invasive and painless
- Suitable for molecules over 500 Da (peptides, antibodies, nucleic acids)
- Suitable for non-lipophilic molecules
- Reproducible
- Can be developed in many different sizes (size determines the level of energy required)
- Rapid temperature increase
- Medications can be delivered on demand.
- High and easy loading of drugs
- Delivery can be arranged through smartphone apps.
- A fixed electrical energy per cm² is required to obtain the thermal effect needed (±50°C).
- The electrical energy required can be obtained by adjusting the amperage or the voltage.
- Powered by AA batteries
- pH 5 to 10