Description
The Neptune photosensitizer and its three variants are peptides coupled with a third-generation PS. The peptide targets a protein that is overexpressed in multiple cancers.
Actions on the tumor and microenvironment (intratumoral vascular endothelial cells and Treg lymphocytes)
In vitro POC:
•More effective than 5-ALA on lung tumor cells (A549)
•More effective than 5-ALA on glioblastoma cells (U87)
•More effective than 5-ALA on bladder carcinoma cells (HTB9)
•No toxicity without illumination
3-step synthesis, soluble in aqueous medium