Description
NEPTUNE and its three variants are peptides coupled to a third-generation photosensitizer. The peptide targets a protein that is overexpressed in multiple cancers.
Effects on tumors and the microenvironment (vascular endothelial cells and intratumoral Treg lymphocytes)
in vitro POC:
•better efficacy than 5-ALA on lung tumor cells (A549)
•better efficacy than 5-ALA on glioblastoma cells (U87)
•better efficacy than 5-ALA on bladder tumor cells (HTB9)
•no toxicity without illumination
Synthesis in 3 steps, soluble in aqueous medium