Description
Prodynov is a third-generation photosensitizer (PS).
It targets folate receptors that are overexpressed in cancer cells of the ovary, liver, and pancreas.
The proof-of-concept conducted to date focuses on peritoneal carcinomatosis.
Under illumination from a dedicated light-delivery device, this photosensitizer exhibits a triple mechanism of action:
- Fluorescence-guided visualization of cancer cells to enable surgical removal
- Lysis of tumor cells that are not accessible surgically
- Activation of the immune system
Additional key features:
- Water-soluble, with higher efficacy than 5-ALA
- “Pre-GMP” synthesis in three steps, with a detailed protocol for the optimized synthetic route
- Analytical method for identification, quantification, and purity assessment
- Method for solubilization and pre-formulation
- ADME-Tox in vitro and in vivo, DMT, PK, efficacy demonstrated in mice and pigs
PI : 1 Patent TRL : POC In vivo (4/5) Partnership : Licensing