Description
Achievements:
In vivo PK results for IV and IN administration:
•t1/2 plasma: 19 min
•t1/2 intranasal: 142 min
•DMTIN: 5 mg/kg (200x MIC)
•DMTIV: 40 mg/kg
No cytotoxicity on HUVEC cells and keratinocytes / Absence of hemolysis on red blood cells /
Good lung exposure
Minimum Inhibitory Concentration: WT strains and clinical strains of A. baumannii: 3.25 μg/mL
μg/mL, 1.25 μM
MucilAir model of two resistant strains of A. baumannii: efficacy at 50-100μM